Table 1.
Mutation | Epithelial Histological Phenotype |
Stromal Phenotype |
Lactation Phenotype |
Stunted Ductal Outgrowth |
Epithelial Proliferation |
Other | Ref |
---|---|---|---|---|---|---|---|
Shh-/- (Tx) | No | No | No | No | ND | 49 | |
Wap-Shh | Yes | Yes | Yes | No | Reduced in dysplasias | Dilated ducts, expanded basal population, hyperplasia | 49 |
Ihh-/- (Tx) | No | No | No | No | ND | 49 | |
Ptch1mes/mes | Yes | ND | ND | Yes | Sometimes increased | Epithelial, stromal, and systemic functions of Ptch1 (undefined) | 53 |
PtchlΔ/+ | Yes | Yes | ND | Yes | Sometimes increased | Strain dependent hyperproliferation | 51 |
MMTV-SmoM2 | Yes | Yes | ND | No | Increased | Incr. branching, decr. stem cell frequency | 57 |
Ad-Cre; SmoM2 | Yes | Yes | ND | No | Increased | Incr branching, altered cell fate | 58 |
Gli1 laczki/ki | ND | ND | No | ND | ND | No overt lactation or embryonic defects | 59 |
MMTV-rtTA; TRE-Gli1 | Yes | Yes | Yes | No | Increased | Tumorigenesis | 60, 86 |
Gli2-/- (Tx) | Yes | Yes | No | No | ND | Ductal dilation, focal dysplasia | 61 |
Gli3xt/xt | ND | ND | ND | ND | ND | Loss of embryonic buds 3 and 5 | 59, 68 |