Table 2.

Here, the percent of breast tumors from the TCGA dataset [1] (left columns) with mutations of different hedgehog network members is listed, together with information on what type of mutation is present. The right hand columns show this information for the METABRIC datasets [2,3]. The TCGA dataset includes 816 samples [1], and the METABRIC datasets include 2051 samples [2,3]. Data obtained with CBioPortal [4,5].

	TCGA	TCGA	METABRIC	METABRIC
Gene	% Breast Cancers with Mutations	Types of Mutations	% Breast Cancers with Mutations	Types of Mutations
Shh	1.5%	Amplifications	2.1%	Amplifications
Ihh	1%	Amplifications, deep deletions	0.2%	Amplifications
Dhh	0.2%	Amplifications	0.3%	Amplifications
Ptch1	1.8%	Missense, with a few amplifications and deep deletions	0.6%	Amplifications
Ptch2	1.8%	Amplifications, with a few deletions, truncations, and missense	1.3%	Amplifications
Smo	1.2%	Amplifications	1.4%	Amplifications
Hhip	0.7%	Amplifications	0.7%	Amplifications
Gli1	1.5%	Amplifications and missense	0.6%	Amplifications
Gli2	1.5%	Missense	0.3%	Amplifications
Gli3	2.6%	Amplifications and missense	2.4%	Amplifications