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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: Nat Neurosci. 2016 Jan;19(1):10–19. doi: 10.1038/nn.4190

Figure 4. Cellular Metabolism Influences Brain Cancer Epigenetic State.

Figure 4

A schematic of metabolic pathways present within a bran tumor cell with emphasis on transport proteins (GLUT3), and enzymatic effectors (IDH1/2 mutations, ACSS2, and ACLY (ATP citrate lyase)), which alter tumor metabolism and ultimately epigenetic programs. The result of the IDH1 mutation is emphasized, which results in the accumulation of 2-hydroxyglutarate, a metabolite that inhibits the function of iron, oxygen, and α-ketoglutarate dependent demethylase enzymes, thus leading to aberrant accumulation of both DNA and histone methylation.