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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Immunity. 2017 Aug 15;47(2):310–322.e7. doi: 10.1016/j.immuni.2017.07.013

Figure 3. Putative identification of vic1 as a non-classical MHC gene.

Figure 3

(A) Production of B6vic1i/i transgenic mice expressing overlapping regions of B6 BACs. BACs are shown with their corresponding chromosomal coordinates (Kb). The region of overlap between BACs J18 and L18 shows common genes.

(B) Phenotypes of BAC transgenic mice. Transgenic and non-transgenic (n/t, data combined from all strains) littermates were infected with MMTV at 6–8 weeks of age and screened for antiviral IgG Abs three months later. Means are combined from 5 independent experiments. p values were calculated using unpaired t test and are shown relative to non-transgenic mice. ≥13 mice per strain were used.

(C) Amino acid alignment of B6, BALB/cJ, C3H/HeN and I/LnJ Ob. Amino acid number 1 corresponds to the first amino acid after signal sequence cleavage. Negative numbers correspond to the amino acid residues of the signal sequence. Protein domains are marked by colored frames.