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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Structure of (A) adenosine A1 receptor bound with the covalent antagonist DU172 (PDB: 5UEN); (B) overlay of the A1 (green) and A2A (red) receptors showing the significant difference in the extracellular loop region (ECL) between the two receptors [26,27].