Table 5.

C statistics and net reclassification improvement statistics of lipid parameters for major cardiovascular events in TNT and IDEAL

Models	C statistics
LDL cholesterol	0.648 (0.634–0.662)
Non-HDL cholesterol	0.650 (0.636–0.664)
Apolipoprotein B	0.651 (0.637–0.665)
Estimated apoB	0.650 (0.636–0.664)
Models	Net reclassification improvement statistics	P
LDL cholesterol vs. apolipoprotein B	3.5% (0.3–6.4)	0.007
LDL cholesterol vs. estimated apoB	3.2% (−0.3–6.4)	0.09
LDL cholesterol vs. non-HDL cholesterol	3.8% (0.5–6.8)	0.013
Estimated apoB vs. non-HDL cholesterol	5.2% (1.7–10.2)	0.013
Estimated apoB vs. apolipoprotein B	1.0% (−1.3–4.0)	0.31
Non-HDL cholesterol vs. apolipoprotein B	1.1% (−1.4–3.9)	0.29

Adjusted for the effects of study, age, and sex