Fig. 3.

An example of an individual who did not show steep increases in DSEG θ. At baseline this patient was 61 years old, 2.25 years since time of stroke, had an EF z-score of − 1.79 and an IPS z-score of − 0.90. (a) Represents the DSEG spectra of the whole cerebrum at each time point and can be compared to the spectrum of the reference brain. The spectra show minimal change, suggesting brain microstructure stability in this individual over time. (b) The spectra extracted from WMH show minimal change over time. In these graphs, the Reference brain spectrum is indicated by the black dotted line, Baseline by the green line, Time 1 by the orange line, Time 2 by the blue line and Time 3 by the red line. (c) Example axial DSEG slices are shown using the radiological convention at each time point with the corresponding DSEG θ value. As suggested by the spectra, changes in the DSEG images are minimal. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)