Fig. 5.

Combination of Salirasib and Exo2 inhibits prostate tumor growth more efficiently than either treatment alone. a, b When PC3-derived xenografts had been established, the SCID mice were randomly divided into four groups for treatment with vehicle, Exo2, salirasib or the combination of Exo2 and salirasib (n = 5/group). Tumor growth was measured by tumor volume and size every 3–5 days (a), and tumor and mouse body weight (b) was calculated at the end of the experiment. c The xenografts were removed from these mice for Western blot with the indicated antibodies. Representative result of Western blot is shown in the left panel and quantitative data are shown in the right panel. d–f The xenografts removed from the drug-treated tumor-bearing mice were processed for IHC with the indicated antibodies. Representative images of IHC are shown in (d, e) and quantitative data are shown in (f). **p < 0.01