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. 2017 Aug 23;12(8):e0183477. doi: 10.1371/journal.pone.0183477

Fig 2. Homozygous ksv mutation in mice causes hearing loss and stereociliary fusion of cochlear hair cells.

Fig 2

A. ABR waveforms from +/+ and ksv/ksv mice at P30. The waveforms from five mice of each genotype represent the ABR to tone-pip stimuli at the highest sound pressure level (dB SPL) at 4, 8, 16 and 32 kHz and are shown in different colors. The locations of ABR peaks I–V are indicated with ranges (two direction arrows) of the negative wave apex in each peak of +/+ mice. B and C. SEM images of stereocilia in the hair cells from the apex area of the cochlea in the +/+ (B) and ksv/ksv (C) mice at P30. The highly magnified images in the white dotted boxes of B and C are shown in the bottom panels (B’ and C’). The fused giant stereocilia (open arrow), bulged base (arrow), loss of tapered region (arrowhead) and bulbous tip (open arrowhead) of the stereocilia detected in the IHCs of ksv/ksv mice (C). Scale bars = 5 μm.