Table 3.
Gene ontology term annotation of male Cluster 9 and female Cluster 3. Italics indicate GO terms that are significant in both clusters. BP: Biological process; CC: Cellular component; MF: Molecular function. Benjamini-corrected p-value
| Cluster | Category | GO ID | Term | P-value |
|---|---|---|---|---|
| C9 Male |
BP | GO:0006396 | RNA processing | <0.001 |
| BP | GO:0034660 | ncRNA metabolic process | <0.001 | |
| BP | GO:0034470 | ncRNA processing | <0.001 | |
| MF | GO:0000166 | nucleotide binding | <0.001 | |
| CC | GO:0031981 | nuclear lumen | <0.001 | |
| MF | GO:0001882 | nucleoside binding | <0.001 | |
| BP | GO:0016071 | mRNA metabolic process | <0.001 | |
| MF | GO:0005524 | ATP binding | <0.001 | |
| MF | GO:0032559 | adenyl ribonucleotide binding | <0.001 | |
| BP | GO:0006397 | mRNA processing | <0.001 | |
| MF | GO:0030554 | adenyl nucleotide binding | <0.001 | |
| MF | GO:0001883 | purine nucleoside binding | <0.001 | |
| BP | GO:0006399 | tRNA metabolic process | <0.001 | |
| CC | GO:0070013 | intracellular organelle lumen | <0.001 | |
| CC | GO:0043233 | organelle lumen | <0.001 | |
| CC | GO:0031974 | membrane-enclosed lumen | <0.001 | |
| MF | GO:0017076 | purine nucleotide binding | <0.001 | |
| MF | GO:0032553 | ribonucleotide binding | <0.001 | |
| MF | GO:0032555 | purine ribonucleotide binding | <0.001 | |
| BP | GO:0022613 | ribonucleoprotein complex biogenesis | 0.002 | |
| MF | GO:0003723 | RNA binding | <0.001 | |
| BP | GO:0008380 | RNA splicing | 0.004 | |
| BP | GO:0042254 | ribosome biogenesis | 0.004 | |
| MF | GO:0004386 | helicase activity | 0.001 | |
| CC | GO:0005730 | nucleolus | 0.003 | |
| MF | GO:0008186 | RNA-dependent ATPase activity | 0.003 | |
| MF | GO:0004004 | ATP-dependent RNA helicase activity | 0.003 | |
| BP | GO:0006364 | rRNA processing | 0.012 | |
| BP | GO:0016072 | rRNA metabolic process | 0.012 | |
| BP | GO:0006360 | transcription from RNA polymerase I promoter | 0.021 | |
| CC | GO:0005654 | nucleoplasm | 0.011 | |
| BP | GO:0006418 | tRNA aminoacylation for protein translation | 0.022 | |
| BP | GO:0043039 | tRNA aminoacylation | 0.022 | |
| MF | GO:0016875 | ligase activity, forming carbon-oxygen bonds | 0.007 | |
| MF | GO:0016876 | ligase activity, forming aminoacyl-tRNA | 0.007 | |
| MF | GO:0004812 | aminoacyl-tRNA ligase activity | 0.007 | |
| BP | GO:0043038 | amino acid activation | 0.023 | |
| MF | GO:0016779 | nucleotidyltransferase activity | 0.007 | |
| MF | GO:0034062 | RNA polymerase activity | 0.006 | |
| MF | GO:0003899 | DNA-directed RNA polymerase activity | 0.006 | |
| MF | GO:0003724 | RNA helicase activity | 0.006 | |
| BP | GO:0035196 | gene silencing by miRNA, production of miRNAs | 0.026 | |
| BP | GO:0035195 | gene silencing by miRNA | 0.028 | |
| MF | GO:0008026 | ATP-dependent helicase activity | 0.013 | |
| MF | GO:0070035 | purine NTP-dependent helicase activity | 0.013 | |
| BP | GO:0000398 | nuclear mRNA splicing, via spliceosome | 0.047 | |
| BP | GO:0000377 | RNA splicing, via transesterification reactions with | 0.047 | |
| BP | GO:0000375 | RNA splicing, via transesterification reactions | 0.047 | |
| MF | GO:0003729 | mRNA binding | 0.015 | |
| MF | GO:0042624 | ATPase activity, uncoupled | 0.018 | |
| MF | GO:0004540 | ribonuclease activity | 0.021 | |
| MF | GO:0032549 | ribonucleoside binding | 0.029 | |
| MF | GO:0003677 | DNA binding | 0.031 | |
| MF | GO:0000287 | magnesium ion binding | 0.038 | |
| MF | GO:0016887 | ATPase activity | 0.040 | |
| C3 Female |
BP | GO:0009451 | RNA modification | 0.002 |
| CC | GO:0030529 | ribonucleoprotein complex | 0.001 | |
| BP | GO:0034660 | ncRNA metabolic process | 0.004 | |
| BP | GO:0034470 | ncRNA processing | 0.003 | |
| BP | GO:0042254 | ribosome biogenesis | 0.006 | |
| BP | GO:0022613 | ribonucleoprotein complex biogenesis | 0.027 | |
| CC | GO:0022625 | cytosolic large ribosomal subunit | 0.020 |