Table 2.
Summary of immnohistochemical findings in previouse reports and present cases
| Author | TTF-1 | Ki67 | CK7 | CK20 | MUC5AC | MUC5B | p53 | HNF4α | p63/p40 | CDX2 | PD-L1 | ALK | BRAF V600E |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sato et al. [8] | 2/2 | 3%; 10% | 2/2 | 0/2 | 1/2 | - | - | - | - | - | - | - | - |
| Chuang et al. [14] | 1/1 | <1% | 1/1 | 0/1 | - | - | 0/1 | - | 1/1 | - | - | - | - |
| Chu et al. [13] | 1/1 | - | 1/1 | 0/1 | - | - | - | - | 1/1 | - | - | - | - |
| Kon et al. [12] | 5/5 | <1%; 5 | 5/5 | 0/5 | 0/5 | - | 0/5 | - | 5/5 | - | - | - | - |
| Lau et al. [15] | 1/1 | not increase | 1/1 | 0/1 | 1/1(weak) | - | - | - | 1/1 | - | - | - | - |
| Kamata et al. [4, 11] | +a | - | - | - | +a (cliated cells) | - | - | 0/10a | +a | - | - | - | 4/4b |
| Ishikawa et al. [16] | 3/5 | <5% 3; <10% 1 | 5/5 | 0/5 | - | - | 3/3 | - | - | - | - | - | - |
| Taguchi et al. [10] | 0/1 | 3.7% | 1/1 | 0/1 | 1/1 | - | <1% | - | 1/1 | - | - | 1/1 | 0/1 |
| Jin et al. [6] | 1/1 | - | 1/1 | - | - | - | - | - | 1/1 | - | - | 1/1 | - |
| Our series | 4/4 | <5% 3; <10% 1 | 4/4 | 0/4 | 4/4 | 4/4 | 1/4 | 4/4 | 4/4d | 0/4 | <1% 4/4 | 0/4 | 1/4c |
-; not available, anumbers of positive/negative not reported, bcases with BRAF mutation, ccase with BRAF mutation was positive (1/1), done case was a few as positive