Table 2.
Cytogenetic characteristics and gene expression level
| Gene expression | Cytogenetic characteristics, n (%) (failed = 15) | |||||
|---|---|---|---|---|---|---|
| CBF-AML | Cytogenetic intermediate-risk | Cytogenetic high-risk | ||||
| t(8;21) | inv(16) | Normal cytogenetics | Others | 11q23 | Others | |
| MECOM | P < 0.001 | |||||
| Low | 34 (12.5) | 9 (3.3) | 181 (66.8) | 34 (12.5) | 5 (1.8) | 8 (3.0) |
| High | 40 (15.3) | 6 (2.3) | 130 (49.6) | 44 (16.8) | 22 (8.4) | 20 (7.6) |
| P | 0.364 | 0.472 | <0.001 | 0.165 | 0.001 | 0.015 |
| MEIS1 | P < 0.001 | |||||
| Low | 72 (26.6) | 1 (0.4) | 152 (56.1) | 30 (11.1) | 6 (2.2) | 10 (3.7) |
| High | 2 (0.7) | 14 (5.1) | 168 (61.3) | 51 (18.6) | 21 (7.7) | 18 (6.6) |
| P | <0.001 | 0.001 | 0.215 | 0.013 | 0.003 | 0.128 |
| SPI1 | P < 0.001 | |||||
| Low | 34 (12.5) | 0 (0.0) | 172 (63.2) | 46 (16.9) | 8 (2.9) | 12 (4.4) |
| High | 40 (14.7) | 15 (5.5) | 148 (54.2) | 35 (12.8) | 19 (7.0) | 16 (5.9) |
| P | 0.463 | <0.001 | 0.032 | 0.179 | 0.031 | 0.444 |
| ERG | P = 0.004 | |||||
| Low | 28 (10.4) | 5 (1.9) | 160 (59.5) | 54 (20.1) | 11 (4.1) | 11 (4.1) |
| High | 46 (16.7) | 10 (3.6) | 160 (58.0) | 27 (9.8) | 16 (5.8) | 17 (6.2) |
| P | 0.033 | 0.208 | 0.721 | 0.001 | 0.358 | 0.274 |
| WT1 | P < 0.001 | |||||
| Low | 55 (20.4) | 0 (0.0) | 152 (56.3) | 41 (15.2) | 8 (3.0) | 14 (5.2) |
| High | 19 (7.0) | 15 (5.5) | 166 (60.8) | 40 (14.7) | 19 (7.0) | 14 (5.1) |
| P | <0.001 | <0.001 | 0.286 | 0.862 | 0.032 | 0.976 |
| GATA2 | P = 0.082 | |||||
| Low | 46 (17.0) | 10 (3.7) | 145 (53.5) | 44 (16.2) | 12 (4.4) | 14 (5.2) |
| High | 28 (10.2) | 5 (1.8) | 175 (63.9) | 37 (13.5) | 15 (5.5) | 14 (5.1) |
| P | 0.021 | 0.183 | 0.014 | 0.370 | 0.574 | 0.976 |
| BAALC | P < 0.001 | |||||
| Low | 9 (3.3) | 0 (0.0) | 180 (66.7) | 48 (17.8) | 21 (7.8) | 12 (4.4) |
| High | 65 (23.6) | 15 (5.5) | 140 (50.9) | 33 (12.0) | 6 (2.2) | 16 (5.8) |
| P | <0.001 | <0.001 | <0.001 | 0.058 | 0.003 | 0.468 |