Table 4.

Multivariate analysis of prognostic value of AML

Variables	CR		OS		DFS
	OR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Age	0.968 (0.957–0.980)	<0.001	1.023 (1.016–1.030)	<0.001	1.018 (1.008–1.028)	<0.001
WBC		NS		NS		NS
Cytogenetic risk	0.894 (0.800–0.998)	0.046	1.093 (1.032–1.158)	0.002	1.106 (1.019–1.201)	0.016
FLT3-ITD/TKD		NS	1.408 (1.074–1.845)	0.013	1.492 (1.010–2.203)	0.044
Biallelic CEBPA		NS	0.524 (0.325–0.845)	0.008		NS
NPM1-mut/DNMT3A-wt	3.389 (1.519–7.562)	0.003	0.523 (0.355–0.770)	0.001		NS
MLL-PTD		NS		NS		NS
DNMT3A mutation		NS		NS		NS
High MECOM	0.576 (0.377–0.880)	0.011	1.642 (1.296–2.081)	<0.001	1.788 (1.319–2.424)	<0.001
High MESI1	0.389 (0.251–0.603)	<0.001	1.432 (1.114–1.840)	0.005		NS
High SPI1		NS		NS		NS

NS no significance