Table 1. The mean escape latency time in Morris water maze.
Groups | Mean escape latency time in MWM (sec) | |||
---|---|---|---|---|
1st day | 2nd day | 3rd day | 4th day | |
Vehicle | 45.57±1.26 | 31.11b±1.40 | 22.125 b±2.32 | 16.84 b±2.05 |
Met | 45.16±2.14 | 32.47b±2.70 | 25.27b±2.07 | 18.83b±2.06 |
Saxa | 47.11± 1.61 | 27.37b±1.92 | 21.27b±2.69 | 16.90b±3.02 |
D-gal | 51.35±1.53 | 45.36a±1.16 | 39.51a±1.79 | 33.80a±1.62 |
D-gal/Met | 46.91±1.28 | 34.11b±2.08 | 21.23b±1.47 | 14.42b±1.18 |
D-gal/Saxa | 50.57± 1.99 | 41.54a±2.24 | 29.75b±2.41 | 22.88b±2.49 |
MWM, Morris water maze; Vehicle, rats treated with distilled water (1.5 ml/kg/day, s.c); Met, rats treated with metformin (500 mg/kg/day, p.o); Saxa, rats treated with saxagliptin (1 mg/kg/day, p.o); D-gal, rats treated with D-galactose (150 mg/kg/day, s.c); D-gal/Met, rats treated with D-galactose and metformin; D-gal/Saxa, rats treated with D-galactose and saxagliptin. Each value represents mean ± S.E; n = 8.
a Significantly different from Vehicle group on the corresponding day at p < 0.05.
b Significantly different from D-gal group on the corresponding day at p < 0.05.