Table 1.
Growth inhibition of three strains of Plasmodium falciparum by frenolicin B
| Strain | Frenolicin B | P450 | 1A2 | 2C8 | 2C9 | 2C19 | 2D6 | 3A4 |
|---|---|---|---|---|---|---|---|---|
| IC50 values (nM)a | ||||||||
| HB3 | 600±100 (8) | 1000±190 (7) | 800±260 (4) | 600±200 (4) | 600±150 (4) | 600±160 (4) | 700±210 (4) | 700±190 (4) |
| Dd2 | 800±200 (10) | 800±150 (7) | 600±130 (4) | 490±70 (4) | 600±140 (4) | 500±100 (4) | 600±120 (4) | 600±140 (4) |
| 7G8 | 800±150 (8) | 1400±260 (7) | 490±30 (2) | 400±20 (2) | 470±5 (2) | 430±30 (2) | 520±20 (2) | 480±2 (2) |
| IC90 values (nM)b | ||||||||
| HB3 | 1500±240 | 3100±750 | 2000±720 | 1600±580 | 1700±590 | 1500±440 | 2000±740 | 1800±630 |
| Dd2 | 2100±490 | 2800±440 | 1800±460 | 2100±660 | 1600±530 | 1500±460 | 2100±670 | 1800±590 |
| 7G8 | 2000±440 | 7400±2917 | 1100±60 | 850±1 | 990±7 | 1000±20 | 1270±60 | 960±50 |
a
Values are reported as IC50±s.e. (number of replicates).
b
Values are reported as IC90±s.e.
The number of replicates is the same as in the IC50 values above. The column P450 refers to frenolicin B incubated with a variety of P450 s, whereas the latter columns refer to frenolicin B incubated with a specific P450 isoform.