Table 4.

Effect of autoclaving on the physicochemical characteristics of PEG-CIP-NLC formulations prepared with higher molecular weight PEG’s pre and post sterilization.

Formulations (PEGylated CIP-NLCs)	Particle Size (nm)		Polydispersity Index (PDI)		Entrapment efficiency (%EE)		Zeta potential (mV)
	Sterilization Stage		Sterilization Stage		Sterilization Stage		Sterilization Stage
	Pre	Post	Pre	Post	Pre	Post	Pre	Post
PEG(2K)-CIP-NLCs	175.6±13	172±8	0.27±0.02	0.26±0.03	88.8±2.2	88.1±0.7	−0.4±0.03	−0.7±0.06
PEG(5K)-CIP-NLCs	207±9	209±12	0.31±0.02	0.32±0.04	80.4±6.7	76.9±2.3	−1.9±0.06	−2.1±0.03
PEG(10K)-CIP-NLCs	280±7	297±11.3	0.36±0.04	0.42±0.07	76.1±4.51	69.2±4.27	−1.4±0.07	−1.5±0.02
PEG(20K)-CIP-NLCs	320±18	cracked	0.45±0.07	cracked	73.6±.9.68	cracked	−0.2±0.03	cracked