Table 3.
Univariate analysis and independent predictive accuracy.
| Neurological performance | Univariate unadjusted odds ratio | |||
|---|---|---|---|---|
|
|
|
|||
| Categories | P value | OR (CI 95%) | Univariate P | ACC (CI 95%)a |
| Clinical variables | ||||
| Age | 0.11 | |||
| Gender | 0.309 | |||
| Hypertension | 0.281 | |||
| Dyslipedemia | 0.694 | |||
| Diabetes | 0.199 | |||
| Smoking habit | 0.465 | |||
| Atrial fibrillation | 0.07 | 2.158 (0.864–5.391) | 0.099 | 0.672 (0.506–0.838) |
| Heart failure | 0.063 | 1.940 (0.945–3.986) | 0.071 | 0.655 (0.486–0.824) |
| Previous myocardial infarction | 0.233 | |||
| Previous revascularization | 0.219 | |||
| Previous stroke | 0.309 | |||
| Chronic renal failure | 0.516 | |||
| DCM | 0.144 | |||
| COPD | 0.544 | |||
| HCM | 0.565 | |||
| Severe valvulopathy | 0.516 | |||
| Number of shocks delivered before ROSC | 0.023 | 3.025 (0.991–9.229) | 0.052 | 0.671 (0.503–0.837) |
| Time to ALS | <0.001 | 10.312 (2.044–52.032) | 0.005 | 0.689 (0.524–0.851) |
| Time performing ALS | 0.007 | 2.770 (1.046–7.336) | 0.04 | 0.676 (0.509–0.84) |
| Background treatment | ||||
| Aspirin | 0.285 | |||
| Thienopyridines | 0.309 | |||
| Betablockers | 0.669 | |||
| Amiodarones | 0.144 | |||
| ACE inhibitors | 0.365 | |||
| ARBs | 0.309 | |||
| Statins | 0.414 | |||
| Calcium antagonists | 0.31 | |||
| Diuretics | 0.314 | |||
| Anticoagulants | 0.133 | |||
| Aldosterone inhibitors | 0.309 | |||
| VF variables | ||||
| Spectral domain | ||||
| Fundamental spectral variables | ||||
| Dominant frequency | <0.001 | 0.089 (0.020–0.403) | 0.002 | 0.884 (0.77–0.988) |
| Median frequency | <0.001 | 0.073 (0.015–0.355) | 0.001 | 0.86 (0.741–0.98) |
| Normalized 80% PSD | 0.005 | 3.121 (1.270–7.669) | 0.013 | 0.579 (0.4–0.75) |
| 1 Hz DF spectral concentration | 0.023 | 2.198 (1.027–4.704) | 0.042 | 0.634 (0.463–0.805) |
| Amplitude spectrum area (AMSA) | <0.001 | 0.053 (0.008–0.362) | 0.003 | 0.85 (0.723–0.977) |
| Spectral Regularity Index | 0.07 | |||
| Derived spectral variables | ||||
| High-to-low peak ratio | <0.001 | 0.073 (0.014–0.372) | 0.002 | 0.817 (0.678–0.954) |
| High-to-low PSD ratio | <0.001 | 0.034 (0.003–0.396) | 0.007 | 0.847 (0.721–0.969) |
| Time domain | ||||
| Mean amplitude | 0.11 | |||
| Approximate Entropy Regularity Index | <0.001 | 0.032 (0.003–0.355) | 0.005 | 0.796 (0.652–0.937) |
a
Univariate predictive accuracy averaged for training (group 1, retrospective) and validation (group 2, prospective). OR represent univariate odds ratios for non-FNP.
AMSA: amplitude spectrum area. PSD: power spectral density. ROSC: return of spontaneous circulation. Other abbreviations as in Table 1.