Fig 10. Percent of inner hair cell (IHC) loss as a function of percent distance (and tonotopic position in kHz) from the OC apex in untreated and HPN-07-treated chinchilla at 3 days, 10 days, 21 days and 6 months after noise exposure.

Significantly less IHC loss was observed in the basal turn of the OC in the HPN-07 treatment group (p < 0.05, 0.01 or 0.001). The data are plotted as mean ± SEM, and “n”represents the number of cochleae. Vertical lines at right of figures show a significant difference of mean values for control (untreated) and HPN-07-treated" groups as determined by two-way ANOVA followed by Bonferroni post-tests: *p <0.05; **p < 0.01; ***p < 0.001. Shaded area demarcates the range of noise exposure centered at 4 kHz.