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Application of iterative pocket-based VLS to myoc-OLF. Ligand RQQ was copied based on a statistically significant pocket similarity (P-value = 0.008) of a pocket in template protein 4BDK (purple) to myoc-OLF (white). The first round of screening provided a nM binder (NSC37433) and the second round increased the affinity into pM (NSC201634) regime.
