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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Immunol. 2017 Jul 24;199(5):1835–1845. doi: 10.4049/jimmunol.1700119

FIGURE 2.

FIGURE 2

Histopathology, C3 deposition, monocyte/macrophage infiltration, and neutrophil infiltration, at day 10, from the WT, FCN B−/− and MASP-2−/−/sMAp−/− mice. Two separate cohorts of WT and MASP-2−/−/sMAp−/− and of WT and FCN B−/− mice were examined. A. Histopathology from all joints for inflammation, pannus formation, cartilage damage and bone damage comparing WT and FCN B −/− mice. B. C3 deposition from all joints in the synovium, on the surface of cartilage and total scores (synovium plus cartilage). C. Mean score of macrophages from the knee joints of mice in WT and FCN B −/− mice. D. Mean score of neutrophils from the knee joints of mice in WT and FCN B −/− mice. E. Histopathology from all joints for inflammation, pannus formation, cartilage damage and bone damage comparing WT and MASP-2−/−/sMAp−/−. F. C3 deposition from all joints in the synovium, on the surface of cartilage and total scores (synovium plus cartilage). G. Mean score of macrophages from the knee joints of mice in WT and MASP-2−/−/sMAp−/− mice. H. Mean score of neutrophils from the knee joints of mice in WT and MASP-2−/−/sMAp−/−mice. All data represent the mean + SEM in first cohort based on n = 8 for WT, and n = 8 for FCN B−/− mice and in the second cohort based on n = 5 for WT and n = 5 for MASP-2/sMAp −/− mice. *p < 0.05 in comparison to the WT mice.