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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Immunol. 2017 Jul 26;199(5):1886–1897. doi: 10.4049/jimmunol.1601066

Figure 1. TNF mediates epithelial β-catenin signaling and proliferation.

Figure 1

(A) Histological inflammatory scores for normal (healthy; n=7), untreated CD (n=8), anti-TNF responsive (n=10) and anti-TNF refractory CD (n=10) patients. Bars denote the average score of each group. (B) Ki67-stained cells per 100 IEC in normal, untreated CD, anti-TNF responsive and anti-TNF refractory CD patients. (C) Immunoblot analysis and densitometry of p-β-catenin552 and cyclin D1 in nuclear fractions of isolated human colonic epithelial cells (n = 2–3 for each group). Values represent mean ± SEM, *p<0.05.