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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: Ther Deliv. 2010 Aug;1(2):307–322. doi: 10.4155/tde.10.20

Table 1.

Comparison of image-guided delivery techniques.

Delivery technique Target Systemic toxicity Tumor penetration
Transarterial chemoembolization Nonresectable hepatocellular carcinoma, cholangeal carcinoma and liver metastases Leakage or blockage of nontumor vessels, portal thrombosis [29] Generally good penetration, but depends on vessel blockage and presence of collateral circulation
Polymer Implants Solid tumors Local toxicity due to poor implant placement, low chance of systemic toxicity Diffusion limitation (mm3) [65,67]
Convection enhanced delivery Malignant gliomas [75] Leakage into white matter tracts [80], corpus callosum [80,94], sulci [93], ventricles [93] Limited if refraction occurs (cm3 in humans and nonhuman primates) [93]
Particles Solid tumors and metastases [7,101] Dependent on delivery technique [6,11,95,98,102] Dependent on administration technique (mm3–cm3) [93,99,103]