. Author manuscript; available in PMC: 2018 Feb 1.

Published in final edited form as: Crit Rev Biotechnol. 2015 Nov 26;37(1):53–68. doi: 10.3109/07388551.2015.1114465

Table 4.

Genetic sequence of the variable heavy (VH) and light (VL) chains of the antibodies including in mAb cocktails proven to be protective in non-human primates in EBOV lethal challenge experiments. The VH and VL sequence of mAb KZ52, protective in guinea pigs but not in human-primates are also included.

mAb	Chain Heavy	Chain Light	Ref
13C6	MGRLTSSFLLLIVPAYVLXQLTLKESGPGI LKPSQTLSLTCSLSGFSLSTSGVGVGWFR QPSGKGLEWLALIWWDDDKYYNPSLKS QLSISKDFSRNQVFLKISNVDIADTATYYC ARRDPFGYDNAMGYWGQGTSVTVSSAK TTAPPVYPLVPGSL	MGIKMKSQTQAFVFAFLWLSGVDGDIV MTQSQKFMSTSVGDRVSLTCKASQNVG TAVAWYQQKPGQSPKLLIYSASNRYTGV PDRFTGSGSGTDFTLTISNMQSEDLADYF CQQYSSYPLTFGAGTKLELRRADAAPTV SIFPPS	^{Hart et al., 2005}
2G4	GGGLMQPGGSMKLSCVASGFTFSNYWM NWVRQSPEKGLEWVAEIRLKSNNYATH YAESVKGRFTISRDDSKRSVYLQMNTLR AEDTGIYYCTRGNGNYRAMDYWGQGTS VTVSSAKTTPPS	ASLSVSVGETVSITCRASENIYSSLAWYQ QKQGKSPQLLVYSATILADGVPSRFSGSG SGTQYSLKINSLQSEDFGTYYCQHFWGT PYTFGGGTKLEIKRAD	^{Hart et al., 2005}
4G7	GPELEMPGASVKISCKASGSSFTGFSMNW VKQSNGKSLEWIGNIDTYYGGTTYNQKF KGKATLTVDKSSSTAYMQLKSLTSEDSA VYYCARSAYYGSTFAYWGQGTLVTVSA AKTTAPS	ASLSASVGETVTITCRASENIYSYLAWYQ QKQGKSPQLLVYNAKTLIEGVPSRFSGS GSGTQFSLKINSLQPEDFGSYFCQHHFGT PFTFGSGTELEIKRAD	^{Hart et al., 2005}
1H3	GAELVKPGASVKLSCTASGFNIKDTYIHW VKQGPEQGLEWIGRIDPANGNTKYDPKF QGKATITADTSSNTAYLQLSGLTSEDTAV YYCARESRISTMLTTGYFDYWGQGTTLT VSSAKTTAPS	AIMSASPGEKVTMTCSASSSVSYMYWY QQKPGSSPRLLIYDTSNLASGVPVRFSGS GSGTSYSLTISRMEAEDAATYYCQQWSS YPYTFGGGTKLEIKRAD	^{Jones et al., 2013}
6D8	MDFGLIFFIVALLKGVQCDVKLLESGGGL VQPGGSLKLSCAASGFDFSRYWMSWVR QAPGKGLEWIGEINPDSSTINYTPSLKDKF IISRDNAKNTLYLQMSKVRSEDTALYYCT RQGYGYNYWGQGTTLIVSSAKTTAPPVY PLVPGSL	MKLPVRLLVLMFWIPASSSDVLLTQIPLS LPVSLGDQASISCRSSQSIVHSNGNTYLE WYLQKPGQSPKLLIYKASNRFSGVPDRF SGSGSGTDFTLKINRVEAEDLGVYYCLQ GSHVPSTFGGGTKLEIKRADAAPTVSIFP PSSKLG	^{Jones et al., 2013}
13F6	MELGLSWIFLVLTLKGVKCEVQVVESGG GLVKPGGSLKLSCAASGFAFSSYDMSWV RQTPEKRLEWVAYISRGGGYTYYPDTVK GRFTISRDNAKNTLYLQMSSLKSEDTAM YYCSRHIYYGSSHYYAMDYWGQGTSVT VSSAKTTAPPVYPLAPGSL	MAWIXLIFFVLHCSGSFSQLVLTQSSSAS FSLGASAKLTCTLSRQHSTYTIEWYQQQ PLKPPRYVMELKKDGSHSTGDGIPDRFS GSSSGADRYLSISNIQPEDEAIYICGVGDT IKEQFVYVFGGGTKVTVLGQPKSTPTLT VFPPSSEELKENKATLVCLISNFSPSGVTV AWKANGTPITQGVDTSNPTKEGNKFMA SSFLHLTSDQWRSHNSFTCQVTHEGDTV EKSLSPAECL	^{Jones et al., 2013}
10C8	GAELVRSGASVKLSCTSSGFNIKDYFLHW VKQRPEQGLEWIGWIDPENGDTEYAPKF QDKATMTADTSSNTAYLHLSSLTSEDTG VYYCNADGNYGKNYWGQGTTLTVSSAK TTAPS	LSLPVSLGDQASISCRSSQSLVHSNGNTF LHWYLQKPGQSPKLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDLGVYFCS QSTHVPPYTFGGGTKLEIKRAD	^{Jones et al., 2013}
7C9	GAELVKPGASVKLSCTASGFNIKDTYMH WVKERPDKGLEWIGRIDPANGNTKCDSR FQGKATITADTSSNTAYLQLSSLTSEDTA VYYCARRIYFGKGFDFWGQGTTLTVSSA KTTAPS	SSLSVSAGEKVTMSCKSSQSLFNSGDQK NYLAWYQQKPGQPPKLLIYGASTRESGV PDRFTGSGSGTDFTLTISSVQAEDLAVYY CQNDQFYPPTFGDGTKLDLKRAD	^{Jones et al., 2013}
5E6	GGGLVKPGGSLKLSCAASGSAFSRYDMS WVRQTPEKRLEWVAYISRGGGFIYYPDT VKGRFTISRDNAKNTLYLQMSSLKSDDT AMYYCARHVYYGSSPLYAMDYWGQGT SVTVSSAKTTAPS	SASFSLGASAKLTCTLSSQHSTFTIEWYQ QQPLKPPKYVMELKKDGSHSTGDGIPDR FSGSSSGADRYLSISNIQPEDEAIYICGVG DTINEQFVYVFGGGTKVTVLG	^{Jones et al., 2013}
5D2	GPGLVRPSQSLSLTCTVTGYSITSDYAWN WIRQFPGNKLEWLGYITNTGSTGFNPSLK SRISITRDTSKNQFFLQLISVTTEDTATYH CARGLAYWGQGTLVTVSAAKTTAPS	LTLSVTIGQPASISCKSSQSLLDSDGKTYL NWLLQRPGQSPKRLIYLVSKLDSGVTDR FTGSGSGTDFTLKISRVEAEDLGVYYCW QGTHSPFTFGSGTKLEIKRAD	^{Jones et al., 2013}
KZ52	EVQLLESGGGLVKPGGSLRLSCAASGFTL INYRXNWVRQAPGKGLEWVSSISSSSSYI HYADSVKGRFTISRDNAENSLYLQXNSL RAEDTAVYYCVREGPRATGYSXADVFDI WGQGTXVTVSSASTKGPSVFPLAPSSKST SGGTAALGCLVKDYFPEPVTVSWNSGAL TSGVHTFPAVLQSSGLYSLSSVVTVPSSSL GTQTYICNVNHKPSNTKVDKKVEPK	ELVXTQSPDSLAVSLGERATINCKSSQSV LYSSNNKSYLAWYQQKPGQPPKLLIYW ASTRESGVPDRFSGSGSGTDFTLTISSLQA EDVAVYYCQQYYSAPLTFGGGTKVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLN NFYPREAKVQWKVDNALQSGNSQESVT EQDSKDSTYSLSSTLTLSKADYEKHKVY ACEVTHQGLRSPVTKSFNR	^{Lee et al., 2008}