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Histologic section from the bone marrow biopsy sample showing mild nodular and interstitial infiltration by small lymphocytes (Giemsa: 200×). CD3 highlights these lymphocytes (100×). CD30 and ALKc are detected by immunohistochemical staining in some of the atypical lymphocytes and become of essential importance to the differential diagnosis with T-cell prolymphocytic leukemia (400×).
