Fig. 1.

Disease relatedness hierarchy. MalaCards contains several layered levels of relatedness. Aliases are integrated through MalaCards sources via their annotations and our text mining heuristics. Disease families are grouped according to textual similarity, e.g. disease types, inheritance, onset etc. Related diseases are obtained via gene sharing GeneAnalytics [12], a descendent of GeneDecks Set Distiller [13], and by searching within MalaCards. A disease SuperPaths conform to sets of diseases indirectly related to each other via the PathCards algorithm (see “Disease-based pathways”)