Table 3.
Potential genetic markers.
| Gene | Polymorphisms | Patients | Ethnic group | Mechanism | Reference | |
|---|---|---|---|---|---|---|
| Arachidonic acid metabolism | CYSLTR1 | _634 C>T, _475 A>C, _336 A>G | NERD: 105, ATA: 110, NC: 125 | Korean | CysLTR1 expression | [74] |
| CYSLTR2 | _819T > G, 2078C > T, 2534A > G | NERD: 134, ATA: 66, NC: 152 | Korean | CysLTR2 expression, LTC4S gene interaction | [75] | |
| EP2 | uS5, uS5b, uS7 | NERD: 198, ATA: 282, NC: 274 | Japanese | Decrease transcription level of EP2, PGE2 braking | [76] | |
| PTGER | PTGER2: _616 C>G, _166 G>A PTGER3: _1709 T>A, PTGER4: _1254 A>G |
NERD: 108, ATA: 93, NC: 140 | Korean | PGE2, TXA2 receptor polymorphism | [77] | |
| TBXA2R | −4684C>, 795T>C | |||||
| PTGER | PTGER3: rs7543182, rs959 | NERD: 243, ATA: 918 | Korean | PGE2 receptor polymorphism | [78] | |
|
| ||||||
| Eosinophil-associated gene | CRTH2 | _446T > C | NERD: 107, ATA: 115, NC: 133 | Korean | Decrease CRTH2 expression and increase eotaxin-2 production | [79] |
| CCR3 | _520T > C | NERD: 94, ATA: 152 | Korean | Higher mRNA expression of CCR3 | [80] | |
|
| ||||||
| HLA | HLA-DPB1 | DPB1∗0301 | 59 NERD, 57 ATA, 48 NC | Polish | [66] | |
| HLA-DPB1 | DPB1∗0301 | 76 NERD, 73 ATA, 91 NC | Korean | [68] | ||
| HLA-DPB1 | rs3128965 | 264 NERD, 387 ATA, 238 NC | Korean | [70] | ||
| HLA-DPB1 | rs1042151 | 117 NERD, 685 ATA | Korean | [69] | ||
NERD: NSAID-exacerbated respiratory disease; ATA: aspirin-tolerant asthma; CysLTR: cysteinyl leukotriene receptor, LT: leukotriene; PG: prostaglandin; TX: thromboxane; CRTH: chemoattractant receptor homologue expressed by type 2 helper T cells; CCR: chemokine receptor; HLA: human leukocyte antigen; DPP: dipeptidyl peptidase.