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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Exp Neurol. 2016 Nov 26;288:153–166. doi: 10.1016/j.expneurol.2016.11.015

Fig 5. Maintaining control levels of tyrosinated tubulin after paclitaxel treatment does not rescue paclitaxel neurotoxicity.

Fig 5

TTL or GFP control lentivirus was added to DRG neurons at 0 DIV and treated with 50 nM paclitaxel for 48 hr starting at 5 DIV prior to immunostaining for tyrosinated tubulin and βIII tubulin at 7 DIV.

A–B) The fluorescence intensity of tyrosinated tubulin signal from axons was normalized to βIII tubulin signal, and fold changes from control were calculated. Scale bar, 20 μm. **p<0.01, ns p=0.18; Student’s t test.

C) Number of retraction bulbs per field was quantified and is expressed as a fold change relative to control. ***p<0.001, *p=0.037, ns p=0.28; Student’s t test.

For (A–C) n= 3 experiments. Ptx, paclitaxel.