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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: Annu Rev Biochem. 2011;80:437–471. doi: 10.1146/annurev.biochem.79.081507.103945

Figure 7.

Figure 7

Partnerships provide a route to specificity in normal and disease states. Models depict ETS protein interactions with other DNA-binding proteins at the promoters or enhancers of distinct target classes. ETS proteins exhibit redundant occupancy of a consensus ETS-binding site in housekeeping promoters (132, 134). In contrast, ETS proteins bind specifically near genes that agree with predicted biological functions in either normal or cancer cells (65, 133–134, 139). Specific interactions are associated with activation (green arrows) or repression (red bar) of target genes. Specific targets are highlighted by co-occupancy of multiple transcription factors [RUNX, serum response factor (SRF), androgen receptor (AR)] implicating partnerships as drivers of specificity. EWS-FLI1 tandem occupancy is inferred from functional and biochemical analyses of binding to GGAA microsatellite repeats (133, 137, 187). See Supplemental Table 4 for database sources of all genomics data.