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Inhibitory concentrations for suppressing 50% viability (IC50) of MCF-7 cells in different schedules (mean±SD, n=4, triplicate experiments). Schedules for free drugs (or polymeric micelles) are described as follows: D(DM): D(DM) alone; G(GM): G(GM) alone; D/G(DM/GM): add D(DM) and G(GM) simultaneously; DG(DMGM): add D(DM) first and G(GM) after 24 h; GD(GMDM): add G(GM) first and D(DM) after 24 h; AMM: AMM alone; and OMM: OMM alone.
