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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: ACS Nano. 2017 Jan 4;11(1):613–620. doi: 10.1021/acsnano.6b06892

Figure 1.

Figure 1

Schematic of the H2O2-responsive vesicles for glucose-mediated insulin delivery: (A) chemical structure of mPEG-b-P(Ser-PBE) and its degradation products; (B) self-assembly of block copolymer mPEG-b-P(Ser-PBE) into vesicles loaded with insulin and GOx. The vesicles are dissociated to release insulin in the presence of a hyperglycemic state; (C) PVs were further integrated into the hyaluronic acid (HA)-based microneedle-array patches for smart insulin delivery in a mouse model of type 1 diabetes.