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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: ACS Nano. 2017 Jan 4;11(1):613–620. doi: 10.1021/acsnano.6b06892

Figure 3.

Figure 3

In vitro glucose-responsive release of insulin from PVs. (A) In vitro released insulin concentration from PVs(E+I) at several glucose concentrations at 37 °C; (B) The release rate (line slope) of insulin as a function of glucose concentration in the release media for PV(E+I) and [PV(1/2E+I) (containing one-half amount of GOx compared to PV(E+I)]; (C) Pulsatile release profile of insulin from PV(E+I) when the glucose concentration changed between 100 and 400 mg/dL alternatively for 10 min each; (D) CD spectra of native insulin solution and insulin released from the PVs incubated with 400 mg/mL glucose. Error bars indicate SD (n = 3).