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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677

Figure 6. Correlation of receptor binding kinetics with signaling and bioactivities induced by IL-13 agonists.

Figure 6

(A–C) Correlation of the pSTAT EC50 induced by IL-13 wt or the indicated IL-13 agonists with their binding parameters KD (top panel), kon (middle panel) and koff (bottom panel). (D–F) Correlation of the TF-1 proliferation EC50 induced by IL-13 wt or the indicated IL-13 agonists with their binding parameters KD (top panel), kon (middle panel) and koff (bottom panel).