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Cytoskeletal structure is modified in melatonin-supplemented ARPE-19 cells. A,C. Control; B,D. Melatonin 100 μM; AlexaFluor488 labeled β-tubulin (green) of control (C) and melatonin treatment (D). Melatonin treatment shows distinct morphological changes in ARPE-19 (A, B). Melatonin induced the formation of neurite-like outgrowth by altering β-tubulin levels (C, D).
