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. 2017 Aug 23;27(9):093910. doi: 10.1063/1.4999612

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© 2017 Author(s).

1054-1500/2017/27(9)/093910/12

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FIG. 2. — SCR-mediated triggered activity following a paced AP in an isolated DAD-prone myocyte. (a) Subcellular Ca²⁺ transients resulting from a paced AP (black trace) and from two different stochastic SCR (inset) events (blue and red traces) originating approximately at time t = 750 ms. (b) V_m traces of the last paced AP (out of 100 pacing cycles) before a 1000-ms pause. Traces taken from the same two experiments in (a). The elevations in the subcellular Ca²⁺ induced membrane depolarizations which either turned into a subthreshold DAD (blue trace) or a full-blown AP (red trace). Inset: $h * j$ evolution for the subthreshold DAD (solid line) in (a) and for the same experiment with a 5-mV negative-shift in the steady-state Na⁺ channel inactivation (dashed line).