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Conduction block of a PVC originating in the HPS (asterisk) in a simulation with a negative-shift in the steady-state Na+ channel inactivation. (a) Activation sequence; (b) Vm distributions in the BiV model at time instants: t1 = 224 ms, the time of the PVC, and t2 = 285 ms; (c) Box plots illustrating the distribution of Vm and at t1 and t2.
