Figure 3.

With connectome imaging data, we can more accurately reconstruct human brain pathways using fiber orientation distribution (FOD)-based tractography and anatomical region of interests (ROIs). (a) ROIs in the medulla and thalamus were used to reconstruct the spinothalamic pathway. (b) For the reconstruction of the fornix bundle, we use multiple ROIs including the hippocampus, a fornix ROI, mammillary body and basal forebrain. Here two of the ROIs were plotted: red: fornix; green: mammillary body. (c) The reconstructed fornix bundle is overlaid with the hippocampal surfaces. Note that two branches to the mammillary body (posterior branch) and the basal forebrain (anterior branch) have been successfully reconstructed. (d) Surface-based ROIs were used for the reconstruction of the uncinated fasciculus. Green: orbital frontal cortex; Red: anterior temporal cortex. (e) The reconstructed uncinated fasciculi on both hemispheres are overlaid with the cortical surfaces. (f) Corpus callosum bundle connecting the precentral gyrus (motor cortex) of both hemispheres has been reconstructed with ROIs including the precentral gyrus and the middle sagittal corpus callosum ROI. Both ROIs are rendered as 3D surfaces in this plot.