Table 2.
Top genome-wide associations with alcohol consumption in each individual race/ethnicity group and in the trans-ethnic meta-analysis
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| Drinker Status | Drinks/Week | ||||||||||
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| SNP | Chr | Position (bp) | Type | Gene | EA | Ethnicity | EAF | OR (95%CI) | P | Beta (95%CI) | P |
| NHW | 0.28 | 1.05 (1.03–1.08) | 6.74×10−5 | 0.04 (0.02–0.05) | 1.05×10−6 | ||||||
| H/L | 0.38 | 0.97 (0.90–1.04) | 0.41 | 0.05 (0.002–0.09) | 0.04 | ||||||
| rs4665985 | 2 | 27,753,878 | Intergenic | GCKR | C | EAS | 0.44 | 1.02 (0.94–1.09) | 0.68 | 0.02 (−0.04–0.08) | 0.58 |
| AA | 0.12 | 1.05 (0.86–1.79) | 0.63 | 0.21 (0.08–0.33) | 0.002 | ||||||
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| Meta | 1.04 (1.02–1.06) | 5.0×10−4 | 0.04 (0.03–0.06) | 2.26×10−8 | |||||||
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| NHW | 0.47 | 0.96 (0.94–0.99) | 0.0014 | −0.03 (−0.05–−0.02) | 8.95×10−8 | ||||||
| H/L | 0.48 | 0.92 (0.85–0.98) | 0.01 | −0.05 (−0.09–−0.01) | 0.02 | ||||||
| rs7686419 | 4 | 39,406,370 | Upstream | KLB | A | EAS | 0.46 | 0.94 (0.87–1.02) | 0.13 | −0.10 (−0.15–−0.04) | 7.67×10−4 |
| AA | 0.45 | 0.97 (0.85–1.73) | 0.61 | 0.01 (−0.08–0.09) | 0.91 | ||||||
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| Meta | 0.96 (0.94–0.98) | 4.08×10−5 | −0.04 (−0.05–−0.02) | 3.41×10−10 | |||||||
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| NHW | 0.05 | 0.79 (0.74–0.84) | 2.47×10−20 | −0.19 (−0.22–−0.16) | 1.91×10−35 | ||||||
| H/L | 0.07 | 0.72 (0.59–0.85) | 4.35×10−7 | −0.21 (−0.30–−0.12) | 2.58×10−6 | ||||||
| rs1229984 | 4 | 100,239,319 | Missense | ADH1B | T | EAS | 0.69 | 0.94 (0.86–1.02) | 0.15 | −0.07 (−0.12–−0.01) | 0.02 |
| AA | 0.03 | 0.61 (0.26–0.69) | 0.004 | −0.11 (−0.39–0.16) | 0.41 | ||||||
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| Meta | *0.79 (0.69–0.91) | *8.0×10−4 | *−0.15 (−0.23–−0.07) | *3.04×10−4 | |||||||
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| NHW | 0.0005 | NA | NA | NA | NA | ||||||
| H/L | 0.03 | NA | NA | NA | NA | ||||||
| rs671 | 12 | 112,241,766 | Missense | ALDH2 | A | EAS | 0.21 | 0.40 (0.29–0.50) | 2.28×10−72 | −0.17 (−0.26–−0.07) | 5.42×10−4 |
| AA | 0.004 | NA | NA | NA | NA | ||||||
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| Meta | NA | NA | NA | NA | |||||||
Abbreviations: Chr, chromosome; bp, base pair (based on UCSC Genome Browser Assembly February 2009 (GRCh37/hg19)); EA, Effect Allele; EAF, Effect Allele Frequency; NWW, non-Hispanic whites; H/L, Hispanic/Latinos; EAS, East Asians; AA, African Americans; Meta, combined trans-ethnic meta-analysis. The combined meta-analysis includes 71 071 non-Hispanic Whites, 7 047 Hispanic/Latinos, 6 034 East Asians, and 2 475 African Americans.
values for random effects model are reported when significant heterogeneity between race/ethnicity groups was detected (I2≥60%; Q≤0.05)
Bold numbers are p-values <5.0×10−8; NA: ALDH2 rs671 was not polymorphic (MAF<0.5%) in non-Hispanic whites and African Americans, and was observed at a low frequency and imputation quality in Hispanic/Latinos, and so was excluded from the analysis in these race/ethnicity groups.