Table 3.

Results in our GERA cohort of SNPs previously associated with alcohol consumption and related phenotypes at genome-wide level significance (p<5×10⁻⁸)

					Non-Hispanic Whites
								Drinker Status			Drinks/Week
Chr	Position (bp)	SNP	Gene	Previous Study	MA	MAF	OR	P	Padjusted	Pcondi	Beta	P	Padjusted	Pcondi
1	173878471	rs1799876	SERPINC1	Xu et al. 2015	G	0.33	0.99	0.43	1.0	–	0.02	0.0026	0.031	–
2	27741237	rs780094	GCKR	Schumann et al. 2016	T	0.41	0.96	0.0011	0.013	0.52	−0.034	2.38 × 10−7	2.86 × 10−6	0.10
3	20375546	rs11128951	SGOL1	Pan et al. 2013	G	0.19	1.05	0.0016	0.019	–	0.003	0.75	1.0	–
4	39414993	rs11940694	KLB	Schumann et al. 2016	A	0.42	0.95	1.93×10−4	0.002	0.17	−0.035	1.37 × 10−7	1.64 × 10−6	0.38
7	50531885	rs11575537	DDC	Pan et al. 2013	T	0.02	1.03	0.48	1.0	–	0.03	0.33	1.0	–
7	69806023	rs6943555	AUTS2	Schumann et al. 2011	A	0.25	1.02	0.095	1.0	–	0.03	4.0×10−4	0.005	–
					East Asians
								Drinker Status			Drinks/Week
Chr	Position (bp)	SNP	Gene	Previous Study	MA	MAF	OR	P	Padjusted	Pcondi	Beta	P	Padjusted
12	111333622	rs10849915	CCDC63	Baik et al. 2011	C	0.23	1.70	4.21×10−28	3.37×10−27	0.79	0.04	0.26	1.0
	111414461	rs12229654	MYL2	Baik et al. 2011	G	0.18	2.31	1.75×10−48	1.40×10−47	0.06	0.10	0.041	0.33
	112645401	rs2074356	C12orf51	Baik et al. 2011	A	0.14	2.41	5.48×10−48	4.38×10−47	0.19	0.11	0.045	0.36
	113409176	rs2072134	OAS3	Baik et al. 2011	A	0.16	1.58	3.24×10−16	2.59×10−15	0.34	0.06	0.22	1.0
					African-Americans
								Drinker Status			Drinks/Week
Chr	Position (bp)	SNP	Gene	Previous Study	MA	MAF	OR	P	Padjusted		Beta	P	Padjusted
4	100190805	rs28864441	LOC100507053	Xu et al. 2015	T	0.16	1.00	1.0	1.0		0.12	0.027	0.11
4	100229017	rs2066702	ADH1B	Xu et al. 2015	A	0.17	1.00	0.97	1.0		0.12	0.026	0.10

Abbreviations: Chr, chromosome; bp, base pair (based on UCSC Genome Browser Assembly February 2009 (GRCh37/hg19)); MA, Minor Allele; MAF, Minor Allele Frequency; Bold numbers are p-values <0.05; P adjusted: p-values adjusted for Bonferroni correction (for 2 phenotypes and the number of SNPs tested for each ethnic group); P condi: p-values adjusted for GCKR rs4665985, KLB rs7686419, or ALDH2 rs671