Table 3.
Predictors of post-LT mortality conditional upon 6 months survival after LT
| Factor | Hazard ratio (95% confidence interval) | p-value |
|---|---|---|
| Number of early hospitalizations | 1.22 (1.18, 1.27) | <0.001 |
|
| ||
| In hospital at six months | 2.32 (1.81, 2.97) | <0.001 |
|
| ||
| Recipient Age (years) (ref. 18–39) | 0.16* | |
| 40–49 | 0.85 (0.58, 1.26) | 0.43 |
| 50–54 | 0.98 (0.67, 1.44) | 0.92 |
| 55–59 | 1.00 (0.68, 1.47) | 0.99 |
| 60–64 | 0.99 (0.66, 1.47) | 0.96 |
| 65 or older | 1.13 (0.78, 1.65) | 0.51 |
|
| ||
| Female recipient | 0.95 (0.83, 1.09) | 0.46 |
|
| ||
| Recipient Race (ref. Caucasian) | <0.001* | |
| African American | 1.38 (1.11, 1.71) | 0.004 |
| Asian | 1.11 (0.81, 1.52) | 0.51 |
| Hispanic/Latino | 0.66 (0.53, 0.82) | <0.001 |
| Other race | 0.97 (0.49, 1.92) | 0.94 |
|
| ||
| Recipient BMI | 0.99 (0.98, 1.00) | 0.01 |
|
| ||
| Recipient diagnosis (ref. non-cholestatic liver disease) | <0.001* | |
| Hepatitis C | 1.59 (1.36, 1.86) | <0.001 |
| Cholestatic liver disease | 0.75 (0.56, 1.01) | 0.06 |
| Hepatocellular carcinoma | 1.69 (1.37, 2.07) | <0.001 |
| Other liver disease | 0.85 (0.65, 1.10) | 0.22 |
|
| ||
| Recipient on life support at LT | 1.72 (1.07, 2.77) | 0.02 |
|
| ||
| Recipient medical condition (ref. not hospitalized) | 0.20* | |
| In ICU | 0.77 (0.52, 1.12) | 0.17 |
| Hospitalized (not in ICU) | 1.09 (0.89, 1.33) | 0.42 |
|
| ||
| Diabetes | 1.06 (0.92, 1.21) | 0.41 |
|
| ||
| ESRD at six months | 1.85 (1.40, 2.46) | <0.001 |
|
| ||
| On dialysis at LT | 1.01 (0.70, 1.45) | 0.97 |
|
| ||
| Ascites (ref. none) | 0.95* | |
| Slight | 0.97 (0.82, 1.16) | 0.77 |
| Moderate | 0.99 (0.80, 1.22) | 0.92 |
|
| ||
| Loge(creatinine) | 1.16 (1.00, 1.35) | 0.06 |
|
| ||
| Loge(bilirubin) | 0.99 (0.91, 1.07) | 0.82 |
|
| ||
| Loge(INR) | 0.62 (0.48, 0.79) | <0.001 |
|
| ||
| Loge(albumin) | 0.62 (0.47, 0.82) | <0.001 |
|
| ||
| Status 1 | 1.16 (0.60, 2.23) | 0.66 |
|
| ||
| Portal vein thrombosis | 0.94 (0.73, 1.22) | 0.65 |
|
| ||
| TIPSS | 1.14 (0.94, 1.39) | 0.19 |
|
| ||
| Donor age (years) (ref. 18–39) | <0.001* | |
| Under 18 | 0.98 (0.74, 1.28) | 0.87 |
| 40–49 | 1.17 (0.98, 1.40) | 0.09 |
| 50–59 | 1.44 (1.20, 1.73) | <0.001 |
| 60–69 | 1.49 (1.20, 1.85) | <0.001 |
| 70 or older | 1.58 (1.21, 2.05) | <0.001 |
|
| ||
| Female donor | 0.97 (0.83, 1.14) | 0.74 |
|
| ||
| Donor race (ref. Caucasian) | 0.23* | |
| African American | 0.89 (0.75, 1.07) | 0.21 |
| Asian | 1.23 (0.86, 1.76) | 0.26 |
| Hispanic/Latino | 1.16 (0.95, 1.42) | 0.15 |
| Other race | 1.12 (0.54, 2.30) | 0.76 |
|
| ||
| Donor height (cm) | 1.00 (0.99, 1.00) | 0.46 |
|
| ||
| Donation after cardiac death | 1.14 (0.86, 1.51) | 0.37 |
|
| ||
| Donor cause of death (ref. all others) | 0.08* | |
| Anoxia | 0.86 (0.71, 1.04) | 0.11 |
| Cardiovascular accident | 0.85 (0.73, 0.99) | 0.04 |
| Split liver | 0.72 (0.39, 1.33) | 0.30 |
|
| ||
| Donor location (ref. local) | 0.12* | |
| Regional share | 1.19 (1.01, 1.41) | 0.04 |
| National share | 1.12 (0.86, 1.45) | 0.39 |
|
| ||
| Cold ischemia time (hours) | 1.00 (0.98, 1.02) | 0.87 |
*
p-value from overall test of significance for all levels of the factor.