Table 1.
Comparison of baseline characteristics of participants included in the study sample versus those excluded.
| Included cohort (n = 1278) |
Excluded cohort (n = 1742) |
p-value | |
|---|---|---|---|
|
| |||
| Male (%) | 65 | 61 | 0.03 |
|
| |||
| Mean age, years, mean (SD) | 63 (11) | 63 (11) | 0.5 |
|
| |||
| Ethnicity-race (%) | < 0.001 | ||
| Non-Hispanic white | 44 | 56 | |
| Hispanic | 39 | 24 | |
| Black | 15 | 18 | |
| Other/multiple | 3 | 2 | |
|
| |||
| Current smoker (%) | 18 | 23 | 0.001 |
|
| |||
| Alcohol use, ≥ 7drinks/week (%) | 12 | 13 | 0.3 |
|
| |||
| Parental history of stroke (%) | 28 | 31 | 0.1 |
|
| |||
| Hypertension, % | 75 | 75 | 0.9 |
|
| |||
| Blood pressure at entry, mmHg, mean (SD) | 143 (20)/78 (11) | 143 (18)/78 (10) | 0.6/0.9 |
|
| |||
| Severity of hypertension (%) | 0.001 | ||
| Normal-prehypertensive | 17 | 22 | |
| Stage 1 | 42 | 40 | |
| Stage 2 | 41 | 37 | |
|
| |||
| Estimated GFR < 60 mL/min/1.73 m2, % | 13 | 17 | 0.01 |
|
| |||
| Prior lacunar stroke (%) | 10 | 11 | 0.3 |
|
| |||
| Prior subcortical TIA (%) | 5 | 5 | 1.0 |
|
| |||
| Diabetes mellitus (%) | 36 | 37 | 0.6 |
|
| |||
| Ischemic heart disease (%) | 9 | 11 | 0.1 |
|
| |||
| Hyperlipidemia (%) | 46 | 51 | 0.01 |
|
| |||
| Multiple old lacunar infarcts on MRI (%) | 42 | 38 | 0.08 |
|
| |||
| White matter hyperinstensities (ARWMC score) | |||
| mean (SD) | 5.6 (4.1) | 5.4 (4.2) | 0.3 |
| 0–4 | 49 | 51 | 0.7 |
| 5–8 | 29 | 28 | |
| 9+ | 22 | 22 | |
Abbreviations: ARWMC; age related white matter changes; GFR, glomerular filtration rate; MRI, magnetic resonance imaging; S3, small subcortical infarcts; SD, standard deviation