Table 2.
Baseline characteristics and MRI findings by cerebral microbleed status
| No CMB (n = 898) |
CMB(s) (n = 380) |
p-value | |
|---|---|---|---|
|
| |||
| Male (%) | 63 | 71 | 0.009 |
|
| |||
| Mean age, years, mean (SD) | 62 (10) | 64 (11) | 0.01 |
|
| |||
| Ethnicity-race (%) | 0.04 | ||
| Non-Hispanic white | 46 | 39 | |
| Hispanic | 37 | 44 | |
| Black | 14 | 16 | |
| Other/multiple | 3 | 2 | |
|
| |||
| Current smoker (%) | 19 | 15 | 0.09 |
|
| |||
| Alcohol use, ≥ 7drinks/week (%) | 12 | 11 | 0.4 |
|
| |||
| Parental history of stroke (%) | 28 | 29 | 0.8 |
|
| |||
| Hypertension, % | 72 | 82 | < 0.001 |
|
| |||
| Severity of hypertension (%) | 0.009 | ||
| Normo-prehypertensive | 17 | 16 | |
| Stage 1 | 45 | 37 | |
| Stage 2 | 38 | 47 | |
|
| |||
| Estimated GFR < 60 mL/min/1.73 m2, % | 12 | 18 | 0.002 |
|
| |||
| Blood pressure at entry, mmHg, mean (SD) | 141 (18)/77 (10) | 147 (23)/80 (12) | < 0.001/< 0.001 |
|
| |||
| Prior lacunar stroke (%) | 8 | 14 | < 0.001 |
|
| |||
| Prior subcortical TIA (%) | 5 | 6 | 0.5 |
|
| |||
| Diabetes mellitus (%) | 39 | 30 | 0.005 |
|
| |||
| Ischemic heart disease (%) | 10 | 9 | 0.6 |
|
| |||
| Hyperlipidemia (%) | 48 | 41 | 0.02 |
|
| |||
| Multiple old lacunar infarcts on MRI (%) | 34 | 59 | < 0.001 |
|
| |||
| White matter hyperintensities (ARWMC score) | |||
| mean (SD) | 4.7 (3.4) | 7.7 (4.7) | < 0.001 |
| 0–4 | 57 | 30 | < 0.001 |
| 5–8 | 28 | 30 | |
| 9+ | 14 | 40 | |
Abbreviations: ARWMC; age related white matter changes; GFR, glomerular filtration rate; MRI, magnetic resonance imaging; SD, standard deviation; TIA, transient ischemic attack