Table 1.
Clinical and biochemical data of examined patients.
| Parameter | Training cohort | Validation cohort | P value |
|---|---|---|---|
| (n = 463) | (n = 261) | ||
| Age (years) | 50.14 ± 11.58 | 49.56 ± 10.84 | 0.504 |
| Gender: female/male (n) | 62/401 | 38/223 | 0.662 |
| Family history: absent/present (n) | 400/63 | 220/41 | 0.439 |
| Drinking: absent/present (n) | 245/218 | 153/108 | 0.138 |
| Smoking: absent/present (n) | 249/214 | 167/94 | 0.008 |
| Cirrhosis: absent/present (n) | 30/433 | 17/244 | 0.986 |
| HBsAg: negative/positive (n) | 68/395 | 45/216 | 0.363 |
| HCVAb: negative/positive (n) | 454/9 | 251/10 | 0.127 |
| MaI: absent/present (n) | 381/82 | 200/61 | 0.066 |
| NγLR: median, range | 137.54, 15.02–1507.96 | 133.59, 16.73–1236.02 | 0.746 |
| SII: median, range | 327.63, 5.72–2260.07 | 318.50, 4.35–2168.96 | 0.833 |
| ALRI: median, range | 24.65, 2.47–417.12 | 23.31, 0.94–320.96 | 0.540 |
| WBC (×109/L) | 6.15 ± 1.99 | 6.23 ± 2.00 | 0.598 |
| NEUT (×109/L) | 3.74 ± 1.70 | 3.80 ± 1.64 | 0.677 |
| LYMPH (×109/L) | 1.70 ± 0.63 | 1.72 ± 0.58 | 0.685 |
| Platelets (×109/L) | 175.62 ± 79.28 | 185.04 ± 82.63 | 0.131 |
| Albumin (g/L) | 39.17 ± 4.46 | 39.13 ± 4.34 | 0.915 |
| Globulin (g/L) | 30.87 ± 5.29 | 31.21 ± 4.96 | 0.388 |
| TBIL (μmol/L) | 17.82 ± 33.40 | 18.86 ± 41.06 | 0.719 |
| DBIL (μmol/L) | 7.94 ± 24.72 | 8.13 ± 25.05 | 0.850 |
| ALT (U/L) | 47.55 ± 43.51 | 45.39 ± 46.75 | 0.369 |
| AST (U/L) | 54.22 ± 55.06 | 53.69 ± 57.51 | 0.801 |
| AFP (ng/ml): median, range | 152.33, 0.23–11602.00 | 161.25, 0.61–10340.00 | 0.549 |
| γ-GT (U/L): median, range | 68.60, 10.00–657.30 | 67.50, 15.10–604.90 | 0.902 |
| Use of NAs: absent/present (n) | 310/93 | 181/44 | 0.306 |
| Tumor size (cm) | 7.82 ± 4.77 | 7.43 ± 4.65 | 0.183 |
| Tumor number: single/multiple (n) | 327/136 | 200/61 | 0.081 |
| Tumor differentiation: I/II/III/IV (n) | 61/180/178/44 | 43/89/91/38 | 0.085 |
| Child-Pugh classification: A/B (n) | 425/38 | 237/24 | 0.648 |
| BCLC stage: 0/A/B/C (n) | 20/232/116/95 | 18/127/78/38 | 0.076 |
| Type of surgical resectiona (Anatomical/non-anatomical) | 282/181 | 165/96 | 0.539 |
aAnatomical resection includes hemihepatectomy, sectorectomy, and segmentectomy; non-anatomical resection includes limited resection and tumor enucleation. n, number of patients; HBsAg, hepatitis B surface antigen; HCVAb, hepatitis C virus antibody; MaI, microvascular invasion; NγLR, neutrophil cell count times γ-glutamyl transpeptidase to lymphocyte count ratio; SII, systemic immune-inflammation index; ALRI, aspartate transaminase to lymphocyte ratio index; WBC, white blood cell; LYMPH, lymphocyte count; TBIL, total bilirubin; DBIL, direct bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AFP, alpha-fetoprotein; γ-GT, γ-glutamyl transpeptidase; NAs, nucleoside analogues; BCLC, barcelona-clinic liver cancer.