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. 2017 Aug 23;7:9246. doi: 10.1038/s41598-017-09557-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of log₂ ratios and the volcano plot for the identified proteins from iTRAQ. Log₂ values for the ratios of 114:115 in NT (A) and 116:117 ratios in PT (B) were used to show good replication in the iTRAQ experiments. The volcano plot shows the collected p-values (C) for the changes in the patterns of all identified proteins. Red spots represent up-regulated DEPs; gray spots are unchanged proteins; and green spots are down-regulated DEPs.