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. 2017 Aug 23;7:9216. doi: 10.1038/s41598-017-10005-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gars mutant embryonic hindbrains and sciatic nerves show no vascular defects. (A,B) Representative single plane (A, top and B) and collapsed Z-stack (A, bottom) images of IB4 and Pecam1 staining (green) in E13.5 hindbrain (A) and one month sciatic nerve (B), respectively. Scale bars = 1 mm (A, top) and 20 μm (A, bottom, and B). (C–E) Capillary diameter (C, P = 0.593), density (D, P = 0.456), and branching density (E, P = 0.278) are all unimpaired in Gars ^C201R/+ E13.5 hindbrains. n = 9 wild-type and 5 Gars ^C201R/+. (F) Mutant sciatic nerves show no difference in capillary density at one month (P = 0.111). n = 4 wild-type and 5 Gars ^C201R/+. All data were analysed with unpaired, two-tailed t-tests. See also Fig. S2.