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. 2017 Aug 23;7:9223. doi: 10.1038/s41598-017-10087-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of Nrf2 was examined using paraffin-embedded tissue sections of five HCV infected cirrhotic liver with HCC by immunohistochemical staining. Nuclear translocation of Nrf2 was seen only in the tumor areas of HCV infected liver cirrhosis with HCC. Most of the non-tumorous hepatocytes in the cirrhotic liver show negative nuclear Nrf2 staining.