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. 2017 Aug 23;7:9223. doi: 10.1038/s41598-017-10087-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Persistent HCV replication induces Nrf2 activation and nuclear translocation. (A) Immunocytochemical staining of HCV core and pNrf2 in HCV infected Huh-7.5 cells at different days after HCV infection. (B) Quantification of core positive and Nrf2 positive infected Huh-7.5 cells, three high-power fields were measured using ImageJ software. ***P < 0. 0001. (C) Activation of ARE-luciferase reporter in uninfected and HCV infected cells at day 12. Two different concentrations of ARE-luciferase plasmid were transfected to Huh-7.5 cells and infected Huh-7.5 cells. After 24 hours, equal amounts of protein lysates were measured for luciferase activity. The luciferase values were normalized to one microgram of protein.