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. 2017 Aug 23;7:9223. doi: 10.1038/s41598-017-10087-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Persistent HCV replication in Huh-7.5 cells promotes cell growth and S-phase entry (A) HCV infected Huh-7.5 cells and uninfected cells were grown in normal growth media for 6 days. Cell numbers were counted daily. Results were shown as mean and standard error from three different experiments. (B) Show percentage of S-phase cells in diploid and tetraploid cell population. Rb loss in HCV culture shows an increase in tetraploidy population. Nrf2 silencing using two siRNAs in infected culture decreased tetraploidy population. (C) HCV infected (day 12) and uninfected Huh-7.5 cells were subjected to cell cycle analysis after propidium iodide staining. There is an increase in S-phase of cell cycle due to Rb loss in HCV infected cells. Silencing Nrf2 using two siRNAs decreased S-phase population.