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. 2017 Aug 23;7:9235. doi: 10.1038/s41598-017-08711-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of iCRT3 administration on plasma levels of organ injury markers after CLP. Male C57BL/6 mice were sham-operated or subjected to CLP with intraperitoneal injection of vehicle (5% DMSO in normal saline) or iCRT3 (5 mg/kg and 10 mg/kg body weight) at 5 h after CLP. Blood samples were collected at 20 h after CLP to measure (A) AST, (B) ALT, and (C) LDH by using the commercial assay kit. Data were expressed as means ± SEM (n = 5–8 mice per group). *P < 0.05 versus sham and ^# P < 0.05 versus vehicle-treated septic animals.