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. 2017 Aug 23;7:9228. doi: 10.1038/s41598-017-10050-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo PT-OCT of melanin. (a) Average PT-OCT signal from the retina for albino mice (no melanin) and pigmented mice (melanin) cohorts (n = 6 eyes per group). Photothermal laser power at 8 mW. Mean with standard deviation shown. **p < 0.01. (b) Example OCT B-scan of a pigmented mouse retina (grayscale) with PT-OCT signal overlaid (green). (c) Example OCT B-scan of an albino mouse retina (grayscale) with PT-OCT signal overlaid (green, no signal visible). The OCT images show fewer retinal layers than in a typical OCT B-scan of a human retina because of the smaller dimensions of a mouse retina and the axial resolution of standard 860 nm OCT systems, which are also used for human retina imaging. The PT-OCT signal represents the change in optical path length, in units of nm. Scale bar: 100 μm. RPE: retinal pigment epithelium. CO: choroid.