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. 2017 Aug 23;7:9228. doi: 10.1038/s41598-017-10050-5

Figure 3.

Figure 3

In vivo PT-OCT of melanin for different photothermal laser powers. (a) Example OCT B-scans (grayscale, left) of a pigmented mouse retina with corresponding PT-OCT signal (overlaid in green on the left, signal alone on the right) collected for different photothermal laser powers (1–8 mW). Scale bar: 100 μm. (b) Average PT-OCT signal for one B-scan (400 A-scans) collected at different photothermal laser powers (same eye as presented in (a)). The width at half-maximum of the signal peaks (dashed black lines) corresponds to the location of the RPE in depth. (c) Mean background signal (excludes the dashed region from (b)) and peak-to-background ratio for one example eye at different photothermal laser powers. Error bar: standard error. (d) Mean PT-OCT signal as a function of photothermal laser power for n = 6 eyes. Error bar: standard deviation. Linear fit y = 1.56x with 95%CI on the fit (red dashed). R2 = 0.91. *p < 0.05 between 1 mW and 0.4 mW (Mann-Whitney U test).